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BREAKTHROUGH DISCOVERY IN NUTRITIONAL IMMUNOLOGY
At the University of California at Berkeley, the
Chairman of the Nutritional Sciences Department
and
senior scientists from the molecular biology department were studying the
biological properties of Diindolylmethane (DIM), a naturally occurring
compound found in Brassica vegetables (broccoli, cauliflower, cabbage), when
they made a remarkable discovery:
DIM is a potent activator of the immune response
system.
DIM is currently being used as a naturopathic treatment for Recurring Respiratory Papillomatosis (RRP) caused by the Human
Papillomavirus (HPV). DIM has also reached Phase III human clinical trials
as a therapeutic candidate for Cervical Dysplasia (also caused by HPV). Until
recently, scientists did not fully understand the molecular mode of action of
DIM against the HPV virus until DIM's immune modulatory pathway was discovered
at UC Berkeley.
ActivaMune is a patented dietary supplement exclusively
licensed from the University of California at Berkeley. The formula contains
a unique bioavailable formulation of Diindolylmethane (DIM) along with other
ingredients that work with it to boost the immune system and support multiple
organs throughout the body.
science
 Immune Modulation
ActivaMune's primary mode of action is that it
increases the sensitivity of cells in the body to the Interferon-Gamma
protein (IFN-G) in addition to increasing the body's Interferon-Gamma
production. Interferon-Gamma is a key signaling protein within the immune
system that boosts the ability of the body to defend itself against
bacterial and viral infections as well as cancer. Increasing
Interferon-Gamma sensitivity and production in the body enhances the immune
system's ability and agility to detect and eliminate viral infections.
In addition to Interferon-Gamma, DIM also
stimulates the production of the Granulocyte
Colony Stimulating Factor (G-CSF) which is directly responsible for
White Blood Cell production in the body, Interlukin-6 (IL-6),
which is responsible for the body's direct anti-bacterial response,
and Interlukin-12 (IL-12) which stimulates the growth and function of
T-Cells which help to fight off pathogens.
Discoverers of DIM
The discoverers
of Diindolylmethane as a potent immune system activator are: Dr. Leonard
Bjeldanes, Professor and Former Chairman of the Department of Nutritional
Sciences and Toxicology at UC Berkeley and Dr. Gary Firestone, Professor and Director of the National Institutes of Health Cancer Research Program at UC
Berkeley. Dr. Bjeldanes and Dr. Firestone are regarded as leading scientific
authorities on Diindolylmethane as together they have published more papers
on DIM than any other research team worldwide.
As immune modulation does not discriminate in the type of infection that it
combats, DIM is currently under investigation as a therapeutic
candidate for all viral and bacterial infections known to man, including
HIV, Hepatitis and antibiotic resistant bacteria.
Scientific Advisory Board
The Scientific Advisory Board members of our
company are internationally renowned scientists in the fields of nutrition,
oncology and immunology:
Dr. Leonard Bjeldanes, Ph.D. Professor and Former
Chairman, Nutritional Sciences Department, UC Berkeley. Dr. Bjeldanes is the
most cited scientist worldwide in the field of Diindolylmethane research.
Dr. Gary
Firestone, Ph.D. Director, National Institutes of Health Cancer Research Program, UC Berkeley.
Dr. Firestone and Dr. Bjeldanes at UC Berkeley have together published more
scientific papers on DIM than any other scientific team worldwide.
Dr. Christopher Benz, M.D. Professor of Medicine in Oncology, UCSF, founder of the first laboratory at UCSF dedicated to breast cancer research, Program Director, Cancer and Developmental
Therapeutics Program, Buck Institute for Age Research.
Dr. Warner Greene, M.D., Ph.D. Professor of Medicine in Immunology, UCSF, Director,
UCSF Gladstone Institute of Virology and Immunology, Board Member,
United States Institute of Medicine, National Academy of Sciences.
Dr. Giuseppe Del Priore, M.D., M.P.H.
Professor of Medicine and Director of Gynecologic Oncology at the Indiana
University School of Medicine. Dr. Del Priore led the successful human clinical
trials of DIM for the treatment of Cervical Dysplasia caused by the HPV virus.
Dosage Recommendation for
HPV Patients
Physicians who have successfully administered our product as
a nutritional supplement to boost the immune of their patients suggest that HPV patients take
4 capsules a day of ActivaMune for a period of at least six months. If
intimacy is occurring between a patient and their partner, it is recommended
that the partner also take the product at the same dosage for the same
period of time.
Note to Consumers
While a tremendous amount of excitement in the scientific
community has occurred since the groundbreaking discovery at UC Berkeley
regarding DIM's immune activating properties and while the compound has
reached advanced Phase III human clinical trials for cervical dysplasia,
Diindolylmethane (DIM) has not yet been approved by the US FDA as a
therapeutic for cervical dysplasia or other HPV conditions. In order for a
therapeutic candidate to be approved as a treatment for a particular
condition, it must go through four progressive human clinical trials.
ActivaMune is an immune enhancing dietary supplement with
Diindolylmethane as one of its natural ingredients.
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